Abstract
BackgroundA rapid and sensitive ultraviolet-visible (UV-VIS) spectroscopic method was developed for the estimation of pyrimidine derivative 6-Bromo-3-(6-(2,6-dichlorophenyl)-2-(morpolinomethylamino) pyrimidine4-yl) -2H-chromen-2-one (BT10M) in bulk form.ResultsPyrimidine derivative was monitored at 275 nm with UV detection, and there is no interference of diluents at 275 nm. The method was found to be linear in the range of 50 to 150 μg/ml. The accuracy and precision were determined and validated statistically. The method was validated as a guideline.ConclusionsThe results showed that the proposed method is suitable for the accurate, precise, and rapid determination of pyrimidine derivative.Graphical Method development and validation of potent pyrimidine derivative by UV spectroscopy.Electronic supplementary materialThe online version of this article (doi:10.1186/s13588-014-0015-9) contains supplementary material, which is available to authorized users.
Highlights
A rapid and sensitive ultraviolet-visible (UV-VIS) spectroscopic method was developed for the estimation of pyrimidine derivative 6-Bromo-3-(6-(2,6-dichlorophenyl)-2-(morpolinomethylamino) pyrimidine4-yl) -2H-chromen-2one (BT10M) in bulk form
Pyrimidine derivatives form a component in various useful drugs and are associated with many biological and therapeutic activities
Chemical and reagent BT10M was synthesized by research workers and validated
Summary
A rapid and sensitive ultraviolet-visible (UV-VIS) spectroscopic method was developed for the estimation of pyrimidine derivative 6-Bromo-3-(6-(2,6-dichlorophenyl)-2-(morpolinomethylamino) pyrimidine4-yl) -2H-chromen-2one (BT10M) in bulk form. Results: Pyrimidine derivative was monitored at 275 nm with UV detection, and there is no interference of diluents at 275 nm. The method was validated as a guideline. Pyrimidine derivatives form a component in various useful drugs and are associated with many biological and therapeutic activities. Condensed pyrimidines have been reported as antimicrobial [1-3], anti-inflammatory [4,5], analgesic [6,7], anticancer [8-10], anti-HIV [11], antitubercular, antimalarial, diuretic, and cardiovascular disease [12] (Scheme 1). The present work is a synthesis, a biological evaluation and validation of novel pyrimidine derivatives. BT10M exhibited maximum antimicrobial, anti-inflammatory, and analgesic activity. A validation study was done on BT10M.
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