Abstract
The aim of this study is to create and validate a fast, easy-to-use, affordable, sensitive, and accurate method for measuring Escitalopram and Flupentixol in bulk and pharmaceutical products using Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). Agilent Eclipse XDB C18 column was used with a running phase composed of 0.1% Tri fluoro acetic acid: Acetonitrile (30:70 v/v) at a flow rate of 1.0 ml/min. UV detection was used at a wavelength of 231 nm. Flupentixol and Escitalopram correlation coefficients were found to be 0.999 over a concentration range of 1.25-7.5 µg/ml and 25-150 µg/ml, respectively. Escitalopram and Flupentixol have respective retention times of 3.235 and 3.858 minutes. The run time for separating Flupentixol and Escitalopram peaks was 6 minutes. This method, proposed as a regular analysis and quality control tool for medications that contain these active drugs either individually or in combinatio, was evident to be a suitable one. Keywords: HPLC, Flupentixol, Escitalopram, Development, Validation.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
