Abstract
The aim of this study is to create and validate a fast, easy-to-use, affordable, sensitive, and accurate method for measuring Fenofibrate and Pitavastatin in bulk and pharmaceutical products using Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). A Luna C18 column was used with a running phase composed of 0.1% trifluoroacetic acid: acetonitrile (30:70 v/v) at a flow rate of 1.0 ml/min. UV detection was used at a wavelength of 240 nm. Pitavastatin and Fenofibrate correlation coefficients were found to be 0.999 over a concentration range of 5-30 µg/ml and 168.75-1012.5 µg/ml, respectively. Pitavastatin and Fenofibrate have respective retention times of 3.310 and 2.126 minutes. The run time for separating Pitavastatin and Fenofibrate peaks was 5 minutes. This method, proposed as a regular analysis and quality control tool for medications that contain these active drugs either individually or in combinatio, was evident to be a suitable one. Keywords: HPLC, Pitavastatin, Fenofibrate, Development, Validation.
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