Abstract
A simple, sensitive and specific liquid chromatographic method was developed for the simultaneous estimation of Rosuvastatin calcium and Losartan potassium in bulk form. Chromatographic conditions included the Column C-18 (Shim-pack) 250 x 4.6 mm, particle size 5 µm , mobile phase acetonitrile, methanol and water pH 3 (orthophosphoric acid) in the ratio 20:25:55 recorded at 233 nm. The retention time were found to be 3.55 and 4.64 min and average percentage recovery 99.42% and 99.63% for Rosuvastatin calcium and Losartan potassium respectively. The proposed method was found to comply with ICH guidelines.
 Keyword: Rosuvastatin calcium, Losartan potassium, RP-HPLC, accuracy and linearity.
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