Abstract
Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challenge. Further and complementary testing based in biochemical alterations may be important to correctly identify thyroid cancer and prevent unnecessary surgery. Fourier-transform infrared (FTIR) spectroscopy is a metabolomic technique that has already shown promising results in cancer metabolome analysis of neoplastic thyroid tissue, in the identification and classification of prostate tumor tissues and of breast carcinoma, among others. This work aims to gather and discuss published information on the ability of FTIR spectroscopy to be used in metabolomic studies of the thyroid, including discriminating between benign and malignant thyroid samples and grading and classifying different types of thyroid tumors.
Highlights
Thyroid cancer’s incidence has spiked in the last decades, still maintaining an overall good prognosis [1]
By allowing the study of all biomolecules that make up the sample under analysis, any metabolomic alteration that may occur is likely to be detected, which could result in the consequent identification of possible early biomarkers for the diagnosis of thyroid cancer
The Fourier-transform infrared (FTIR) spectroscopy technique is one of the metabolomic methods that has shown to be very promising with regard to the diagnosis of various types of cancer, including of the thyroid gland
Summary
Thyroid cancer’s incidence has spiked in the last decades, still maintaining an overall good prognosis [1]. FTIR has already shown promising results in cancer metabolome analysis of tissues, in the identification and classification of prostate tumor tissues and of breast carcinoma, and was used in metabolomic studies of thyroid, enabling the discrimination between benign and malignant thyroid samples and grading and classifying different types of thyroid tumors. This works aims to gather the published data on the application of FTIR in the metabolome of the thyroid gland
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