Abstract
The blood level of glucose, glycosylated hemoglobin, triglycerides, total cholesterol, summary content of very low density and low density lipoproteins, high density lipoproteins glycosylation's degree had been decreased with the nettle (Urtica dioica) extract in experimental diabetes mellitus type II in rats that was being caused with streptozotocine intraperitoneal injection and high-fat diet. The effect did not depend on food regimen during the therapy. The cholesterol atherogenic index has been decreased and the sensitivity to insulin has been recovered with the nettle extract when high-fat diet only. The level of blood glucose and glycosylated hemoglobin has been decreased with metformin when usual food regimen during the therapy. The lipid content and cholesterol atherogenic index has been normalized with metformin when both variant of diet.
Highlights
The blood level of glucose, glycosylated hemoglobin, triglycerides, total cholesterol, summary content of very low density and low density lipoproteins, high density lipoproteins glycosylation’s degree had been decreased with the nettle (Urtica dioica) extract in experimental diabetes mellitus type II in rats that was being caused with streptozotocine intraperitoneal injection and high-fat diet
The effect did not depend on food regimen during the therapy
The cholesterol atherogenic index has been decreased and the sensitivity to insulin has been recovered with the nettle extract when high-fat diet only
Summary
Yakimova T.V., Nasanova O.N., Meleshko M.V., Burkova V.N. © ßêèìîâà Ò.Â., Íàñàíîâà Î.Í., Ìåëåøêî Ì.Â., Áóðêîâà Â.Í. Âûçâàííîì ó êðûñ ââåäåíèåì ñòðåïòîçîòîöèíà è äèåòîé ñ âûñîêèì ñîäåðæàíèåì æèðà, ýêñòðàêò êðàïèâû ñíèæàë â êðîâè óðîâåíü ãëþêîçû, ãëèêèðîâàííîãî ãåìîãëîáèíà, òðèãëèöåðèäîâ, îáùåãî õîëåñòåðîëà, ñóììàðíîå ñîäåðæàíèå ëèïîïðîòåèíîâ íèçêîé è î÷åíü íèçêîé ïëîòíîñòè, ñòåïåíü ãëèêèðîâàíèÿ ëèïîïðîòåèíîâ âûñîêîé ïëîòíîñòè íåçàâèñèìî îò ïèùåâîãî ðåæèìà â ïåðèîä òåðàïèè, óìåíüøàë õîëåñòåðîëîâûé èíäåêñ àòåðîãåííîñòè, âîññòàíàâëèâàë ÷óâñòâèòåëüíîñòü ê èíñóëèíó òîëüêî íà ôîíå äèåòû, îáîãàùåííîé æèðîì. Ìåòôîðìèí ñíèæàë â êðîâè óðîâåíü ãëþêîçû è ãëèêèðîâàííîãî ãåìîãëîáèíà ó æèâîòíûõ ïðè îáû÷íîì ïèùåâîì ðàöèîíå âî âðåìÿ òåðàïèè, íîðìàëèçîâàë ñîäåðæàíèå ëèïèäîâ è èíäåêñ àòåðîãåííîñòè ïðè îáîèõ âàðèàíòàõ äèåòû. The level of blood glucose and glycosylated hemoglobin has been decreased with metformin when usual food regimen during the therapy. Öåëüþ ëå÷åíèÿ ñàõàðíîãî äèàáåòà (ÑÄ) òèïà 2 ÿâëÿåòñÿ ïîääåðæàíèå ïîñòîÿííîãî óðîâíÿ ãëèêåìèè, áëèçêîãî ôèçèîëîãè÷åñêîìó ïðîôèëþ ñåêðåöèè èíñóëèíà [1, 3]. Öåëü èññëåäîâàíèÿ — èçó÷åíèå âëèÿíèÿ ýêñòðàêòà êðàïèâû äâóäîìíîé íà ìåòàáîëèçì óãëåâîäîâ è ëèïèäîâ ïðè ìîäåëè ÑÄ, âûçâàííîãî ñòðåïòîçîòîöèíîì
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