Abstract
ABSTRACTPurpose:To evaluate the effects of different high-fat diets on body mass, carbohydrate metabolism and testicular morphology in rats seven months old.Materials and Methods:Male Wistar rats were divided into four groups: SC (standard chow), HF-S (high fat diet rich in saturated fatty acids), HF-P (high fat diet rich in polyunsaturated fatty acids), HF-SP (high fat diet rich in saturated and polyunsaturated fatty acids). The rats were fed for 16 weeks. Blood samples, testes and genital fat deposits were collected for analysis. Data were analyzed by one-way ANOVA and Bonferroni post hoc test, considering p<0.05 as statistically significant.Results:Different high-fat diets promoted an increase in the body mass (p<0.0001). The genital fat deposits were higher in the high-fat groups (HF-S, HF-P, HF-SP) (p=0.0004). Regarding serum parameters, the animals in the HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030) and hypercholesterolemia (p=0.0021). All of the hyperlipidemic groups showed hyperleptinemia (p=0.0019). Concerning the testis, the HF-S group showed a reduction on the seminiferous epithelium height (p=0.0003) and cell proliferation (p=0.0450). Seminiferous tubule diameter was lower in the HF-SP than in the SC group (p=0.0010).Conclusions:The high fat diet administration, independent of the lipid quality, promotes overweight. Diet rich in saturated fatty acids (lard) alters the carbohydrate metabolism and the testicular morphology with reductions of seminiferous epithelium height, seminiferous tubule diameter and cell proliferation which could be related to a disturbance of spermatogenesis.
Highlights
The World Health Organization (WHO) estimates that more than half a billion adults are obese and approximately three million people die as a result of obesity per year (1)
The aim of the present study was to evaluate the body mass, carbohydrate metabolism and testicular morphology in Wistar rats at seven months old that were fed with different high-fat diets
Food intake and body mass Throughout the experiment, the had a greater epididymal fat mass (HF-S), HF-P and HF -SP groups showed an increase of food intake
Summary
The World Health Organization (WHO) estimates that more than half a billion adults are obese and approximately three million people die as a result of obesity per year (1). Several studies have shown an inverse relationship between the body mass index (BMI) and hyperleptinemia in male reproductive parameters. Leptin can act to lower the testosterone level, implying in hypogonadism (3). The fat rich-diets affect the organization of the plasma membrane. One of the consequences in the testes is the altered availabiliibju | High-fat diets and testicular effects ty of gonadotropin receptors, such as luteinizing hormone (LH) and follicle stimulating hormone (FSH), comprising testosterone production by the Leydig cells (interstitial) and spermatogenesis by the cells of the seminiferous tubules, respectively (4)
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