Meta analysis of clinical efficacy of fluconazole combined with clotrimazole in the treatment of candida vaginitis

Abstract

Objective To explore the clinical efficacy of oral fluconazole combined with clotrimazole vaginal administration in the treatment of candida vaginitis by meta analysis. Methods Fluconazole combined with clotrimazole was selected as experiment group and clotrimazole alone was selected as control group. The randomized controlled trials(RCTs) were retrieved from PubMed, Cochrane library, Embase, China Notional Knowledge infrastructure(CNKI), WangFang and VIP database and references listed in all studies. RCTs meeting inclusive studies were included, the data were extracted, the quality was evaluated and cross-checked by two reviews independently according to Cochrane Handbook for Systematic Reviews of Interventions and then Meta-analysis was conducted using Stata14.0 software. Results A total of 15 studies and 1 792 patients were included.The experiment group had a higher overall efficiency(experiment group in 96.13% and control group in 83.8%), the difference was statistically significant (RR=1.13, 95%CI 1.08~1.18, P<0.001). The recurrence rate after treatment(experiment group in 6.46% and control group in 20.74%) had statistically significant difference between the two groups (RR=0.31, 95%CI 0.21~0.46, P<0.001). Conclusion Meta analysis showed that oral fluconazole combined with clotrimazole vaginal administration has a better clinical efficacy. Key words: Candidiasis, vulvovaginal; Randomized controlled trial; Meta-analysis; Fluconazole; Clotrimazole; Effective rate; Relapse rate