Abstract
Mesoporous silica nanomaterials (MSNs) have made remarkable achievements and are being thought of by researchers as materials that can be used to effect great change in cancer therapies, gene delivery, and drug delivery because of their optically transparent properties, flexible size, functional surface, low toxicity profile, and very good drug loading competence. Mesoporous silica nanoparticles (MSNPs) show a very high loading capacity for therapeutic agents. It is well known that cancer is one of the most severe known medical conditions, characterized by cells that grow and spread rapidly. Thus, curtailing cancer is one of the greatest current challenges for scientists. Nanotechnology is an evolving field of study, encompassing medicine, engineering, and science, and it has evolved over the years with respect to cancer therapy. This review outlines the applications of mesoporous nanomaterials in the field of cancer theranostics, as well as drug and gene delivery. MSNs employed as therapeutic agents, as well as their importance and future prospects in the ensuing generation of cancer theranostics and drug and therapeutic gene delivery, are discussed herein. Thus, the use of mesoporous silica nanomaterials can be seen as using one stone to kill three birds.
Highlights
Irregular and uncontrollable cell growth is highly associated with cancer
An early example of their utility involved a process in which folic acid (FA) was synthesized, and modified mesoporous silica nanomaterials (MSNs) were used for targeted transfer of the water-resistant anticancer medication camptothecin [12,13]
It was detected that doxorubicin-loaded mesoporous silica nanoparticles (MSNPs) with a particle size of 40 nm exhibited stronger penetrability across the blood–brain barrier (BBB) and were capable of disrupting the VM capability of glioma cells by controlling the expression of FAK, E-cadherin, and MMP-2, and as a result achieving reasonable anti-glioblastoma efficacy and preventing the undesirable toxic adverse effects on viable brain tissue
Summary
Irregular and uncontrollable cell growth is highly associated with cancer. With metastasis and invasion associated with malignant phenotypic behavior, cancer aggressively attacks diverse areas of the human body and is widely believed to be one of the most long-lasting ailments worldwide [1,2]. In addition to not being cell-specific, the nuisance of multidrug resistance (MDR), exhibited by most cancer cells, poses as a serious limitation and contributes to the low therapeutic index (TI) of chemotherapy [5] Other systems, such as photodynamic therapy (PDT), which employ agents that are photosensitizing in nature to destroy cancer cells, have been proposed. As the foremost Food and Drug Administration (FDA)-accepted nanodrug, is a distinctive example, in which Doxorubicin (DOX) stays encapsulated in a liposome complex to ensure sustained flow time and bioavailability of the drug, as well as minimal adverse effects towards cardiac muscles and other body tissues [8] As another example, in 2011, Cornell dots (C-dots) were accepted by the Food and Drug Administration (FDA) for a stage-I human clinical trial, becoming the earliest silica-based cancer indicative nanoparticles. This concise review paper highlights the up-to-date advancements in the field of nucleic acid delivery using MSNs, for the conveyance of pDNA and siRNA and the combinatorial delivery of nucleic acids and drugs
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call