Mesoporous Silica as a Carrier for Amorphous Solid Dispersion

Smruti Chaudhari,Anshul Gupte

doi:10.9734/bjpr/2017/33553

Abstract

In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms. The bioavailability of these drugs can be increased by formulating these drugs as an amorphous drug delivery system. Use of porous media like mesoporous silica has been investigated as a potential means to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. These materials have nanosized capillaries and the large surface area which enable the materials to accommodate high drug loading and promote the controlled and fast release. Therefore, mesoporous silica has been used as a carrier in the solid dispersion to form an amorphous solid dispersion (ASD). Mesoporous silica is also being used as an adsorbent in a conventional solid dispersion, which has many useful aspects. This review focuses on the use of mesoporous silica in ASD as potential means to increase the dissolution rate and to provide or increase the stability of the ASD. First, an overview of mesoporous silica and the classification is discussed. Subsequently, methods of drug incorporation, the stability of dispersion and, much more are discussed.

Highlights

Combinatorial chemistry and high-throughput screening of drugs has led to the discovery of more and more poorly water soluble drugs [1,2,3]
The purpose of this review is to focus on the use of mesoporous silica in amorphous oral drug delivery system
The loading of the ibuprofen and ITZ in ordered mesoporous silica by melt method depends on the drug molten viscosity, while the ability to form a homogeneous mixture of drug and silica prior to the melting step of the process depends on the density of the powders and method of blending

Summary

Introduction

Combinatorial chemistry and high-throughput screening of drugs has led to the discovery of more and more poorly water soluble drugs [1,2,3]. The concept of solid dispersion was introduced by Sekiguchi and Obi [16] and it has become the preferred and most successful method to enhance the drug dissolution and to stabilize the amorphous solid dispersion (ASD). The addition of polymer to ASD will help to stabilize the system by reducing the mobility of the drug molecules and by increasing the glass transition temperature of the glass solutions as compared to pure amorphous drugs, and kinetically act as crystallization inhibitors [22,23,24]. Some scientists have proved that the drug-polymer interactions are important for stabilization of ASD [22,25,26]

Objectives

Methods

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Conclusion