Meroterpenoids from Ganoderma petchii inhibiting migration of triple negative breast cancer cells

Abstract

Ganoderpetchoids A−E and (−)-dayaolingzhiol H, six undescribed meroterpenoids, were isolated from Ganoderma petchii. Their structures including the relative configurations were identified by means of spectroscopic methods and 13C NMR calculations. Chiral separation of the new racemics was performed to afford their respective enantiomers. The absolute configurations of the new isolates were clarified by computational approaches, CD comparisons and X-ray diffraction analysis. Biological studies toward triple negative breast cancer indicated that (+)-6 and (−)-6 significantly inhibit the migration of MDA-MB-231 cell line.