Abstract
The aim of this workis to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the familyLamiaceaeL., which were sources of biologically active substances, pharmaceutical substances, total extracts and the drugs – with a neurotropic activity.Materials and methods.For the review, we used the information of scientific literature from open and accessible sources of the last twenty years, located in the scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, PubMed, Scopus, Cyberleninka, GoogleAcademy, J-Stage. The search inquiries were: the species of the familyLamiaceae(Russian and Latin), the samples of medicinal plant materials based on them as well as the names of the drugs and biologically active substances obtained from these raw materials.Results.When working with the sources of scientific information, the main attention was paid to pharmacologic tests performed during the studies on laboratory animals and proving the presence of neurotropic activity in the studied objects – essential oils and extracts from plant raw materials: aqueous, aqueous alcoholic, and methanol ones. It has been established that the potential of the therapeutic and preventive application of pharmaceutical substances and drugs based on the medicinal plant materials obtained from 30 genera members of theLamiaceaefamily, remains unrealized despite the close attention of various researchers.Conclusion.This review comprised 71 species from 30 genera. Despite the significant level of the previous study presented in the analysis of this publication, an enormous potential of this family’s species remains unexplored. In the future, they can be of both – pharmacognostic and practical interest, in particular, in creation of new medicinal preparations of the neurotropic action based on them.
Highlights
In the modern world, in conditions of excessive intense and inadequately prolonged stressful effects of various external factors, a human body needs therapeutic and preventive agents that have a protective neurotropic, or neuroprotective, effect
Extractive drugs, biologically active food additives, separate fractions of biologically active substances and standardized medicinal preparations obtained from the medicinal plant materials of the members of the family Valerianaceae, Paeoniaceae (Paeónia anómala herb, rhizomes and roots), Hypericaceae (Hypericum perforatum herb), Passifloraceae (Passiflora incarnata herb), Polemoniaceae (Polemonium coeruleum rhizomes with roots), Lamiaceae (Leonurum cardiaca herb), which have pronounced neurotropic, mainly sedative, activities, are widely known [6]
The analysis of the publications on plant raw materials obtained from members of the family Lamiaceae, extracts or separate classes of biologically active substances, makes it possible to conclude that they comprise about 30 genera
Summary
In conditions of excessive intense and inadequately prolonged stressful effects of various external factors, a human body needs therapeutic and preventive agents that have a protective neurotropic, or neuroprotective, effect. All types of stress, which is considered a combination of exogenous and endogenous negative factors that create tension in the human body, are characterized by unspecific reactions of the hypothalamic-pituitary-adrenocortical system гипоталамо-гипофизарно-адренокортикальной системы and disorders of vegetal functions нарушения вегетативных функций of the cardiovascular and hematopoietic systems. The advantage of herbal drugs created on the basis of modern scientific achievements, is the presence of a wide range of biologically active substances with multi-directional therapeutic and preventive agents in their composition. In most cases, these properties are combined with safety and the possibility of a long-term use. The possibilities of creating new drugs and biologically active additives, therapeutic and prophylactic agents containing biologically active substances from raw materials of plant species of the family Lamiaceae, remain unrealized and need further comprehensive researches
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