Abstract

MELANOMA -Diagnosis, Pathology and Molecular Biology

Highlights

  • Melanoma is one of the tumors where diagnosis, monitoring and treatment have been most developed with determinations that include the use of molecular biology

  • In the more advanced tumor stages, ultrasound, computed tomography or positron emission tomography are recommended for the proper evaluation of the tumor

  • Testing for treatable mutations is mandatory in patients with resectable or unresectable stage III or stage IV melanoma and is highly recommended for high-risk resected stage IIC melanoma, but not for stage I or stage IIA-IIB melanoma

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Summary

Staging and Risk Assessment

Physical examination is essential with special attention to the following:. Other suspicious pigmented lesions. EORTC 1325-MG / Keynote-054 is a phase 3 study that randomized fully resected stage III melanoma patients to receive 200 mg fixed-dose pembrolizumab every 3 weeks for one year or placebo In this update at 3 years of follow-up, pembrolizumab confirmed its benefit in progression-free survival with 63.7% (95% CI: 59.2 - 67.7) of living patients and without recurrence compared to 44.1% ( 95% CI: 39.6 - 48.4) of those treated with placebo (HR: 0.56; 95% CI: 0.47 - 0.68; p

Role of Immunotherapy in Neoadjuvant
Findings
Objective
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