Abstract
MELANOMA -Diagnosis, Pathology and Molecular Biology
Highlights
Melanoma is one of the tumors where diagnosis, monitoring and treatment have been most developed with determinations that include the use of molecular biology
In the more advanced tumor stages, ultrasound, computed tomography or positron emission tomography are recommended for the proper evaluation of the tumor
Testing for treatable mutations is mandatory in patients with resectable or unresectable stage III or stage IV melanoma and is highly recommended for high-risk resected stage IIC melanoma, but not for stage I or stage IIA-IIB melanoma
Summary
Physical examination is essential with special attention to the following:. Other suspicious pigmented lesions. EORTC 1325-MG / Keynote-054 is a phase 3 study that randomized fully resected stage III melanoma patients to receive 200 mg fixed-dose pembrolizumab every 3 weeks for one year or placebo In this update at 3 years of follow-up, pembrolizumab confirmed its benefit in progression-free survival with 63.7% (95% CI: 59.2 - 67.7) of living patients and without recurrence compared to 44.1% ( 95% CI: 39.6 - 48.4) of those treated with placebo (HR: 0.56; 95% CI: 0.47 - 0.68; p
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