Abstract

FDG-PET Metabolic Vs CT Anatomical Monitoring of Tumor Response to Anterior Chemotherapy in Breast Carcinoma-The Uncertainties

Highlights

  • The spectrum of utility of FDG-PETCT in Breast cancer extends from, staging, early assessment of response to treatment, monitoring metastatic tumors for evaluating disease status at follow up [1]

  • FDG PET tumor to HPE correlation -sensitivity, specificity, PPV, NPV SENSITIVITY 88.8% SPECIFICITY 50% PPV 85.7% NPV 57.1% our results show the high sensitivity and low specificity of PETCT in detecting residual tumor

  • PETCT aids in differentiating necrotic area from viable tumor area and a decrease in SUV uptake post NACT is an indication of treatment response, there appears to be uncertainties in the sensitivity and specificity of PETCT detection of pathological tumor and nodal status

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Summary

Introduction

The spectrum of utility of FDG-PETCT in Breast cancer extends from, staging, early assessment of response to treatment, monitoring metastatic tumors for evaluating disease status at follow up [1]. Neoadjuvant chemotherapy in breast carcinoma aids in downsizing tumor, improves chances of breast conservation surgery and eliminates micro-metastasis [2]. Monitoring metabolic response post neoadjuvant chemotherapy has been a useful tool to plan surgery, predict response to therapy and outcomes [3]. Literature suggests PETCT to be more accurate for NACT response monitoring because of its superiority to current imaging studies for distinguishing tumor tissue from necrotic or fibrotic tissue [4]. Several studies have reported the usefulness of volumetric monitoring of treatment response in Breast carcinoma using MRI [5]. Our study compares the FDG PET and CT response predictivity to pathological tumor response

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