Abstract
Aromatic plants are often used as natural medicines because of their remedial and inherent pharmacological properties. Looking into natural resources, particularly products of plant origin, has become an exciting area of research in drug discovery and development. Aromatic plants are mainly exploited for essential oil extraction for applications in industries, for example, in cosmetics, flavoring and fragrance, spices, pesticides, repellents and herbal beverages. Although several medicinal plants have been studied to treat various conventional ailments only a handful studies are available on aromatic plants, especially for radioprotection. Many plant extracts have been reported to contain antioxidants that scavenge free radicals produced due to radiation exposure, thus imparting radioprotective efficacy. The present review focuses on a subset of medicinally important aromatic plants with radioprotective activity.
Highlights
The radical scavenging and antioxidant properties such as reduction in radiation-induced lipid peroxidation are some of the notable characteristics of aromatic plant extracts studied in various models of radiation insult
Executive summary r The enhanced adverse effect of synthetic drugs and antibiotics has paved way toward the utilization of natural products of plant origin unambiguously in recent years. r The present review explored the protection against cellular damage resulting from radiation of approximately thirty aromatic plant extracts or plant-derived compounds. r Many aromatic plant extracts or plant products have shown significant radioprotection in different model systems such as in vivo, ex vivo and/or in vitro. r It is a well-known fact that radiation is a powerful cytotoxic agent
Reactive oxygen species such as superoxide anion, singlet oxygen, hydroxyl radical, nitric oxide, hydrogen peroxide and peroxyl radicals generated by ionizing radiation in biologic system causes cellular injury due to lesions in DNA and proteins. r The radical scavenging and antioxidant properties such as reduction in radiation-induced lipid peroxidation are some of the notable characteristics of aromatic plant extracts studied in various models of radiation damage. r In most of the studies, it has been shown that while protecting against the detrimental effects of radiation, there is a capacity to significantly increase the survival rates of small animals exposed to radiation
Summary
Aromatic plants are often used as natural medicines because of their remedial and inherent pharmacological properties. Lay abstract: Aromatic plants have been used as natural medicines since prehistoric times They are currently mainly utilized for essential oil extraction and are widely used in cosmetics, flavoring and fragrance, spices, pesticides, repellent and herbal beverages. The present review focuses on certain medicinally important aromatic plants with special reference to their radioprotective effects. The antioxidant activities of aromatic plants is influenced by various factors such as growing conditions, methods of processing/extraction and importantly constituents of the antioxidants [29]; the methods involved in determination of antioxidant capacity as well as extraction play a crucial role [30] It is a well-known fact that radiation is a powerful cytotoxic agent. The present review focused on medicinally important aromatic plants with special reference to radioprotective activity (Table 1).
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