Mechanism and Therapeutic Value of Exosomes in Gastric Cancer

Abstract

<i>Background</i> Gastric cancer is a common gastrointestinal tumor with a high incidence and mortality rate, which is a serious threat to life and health; therefore, early diagnosis and interventions are particularly important. Currently, emerging gastric cancer-related targets Exosomes (EXOs) are being explored, (EXOs) are various bioactive substances, such as proteins, nucleic acids and lipids, actively secreted by various cells. It has been shown that exosomes are extensively involved in substance exchange and signal transduction between gastric cancer cells, affecting tumor proliferation and metastasis. Exosomes are biomarkers for the diagnosis and prognosis of gastric cancer, and are one of the hot spots in cancer research. <i>Objective</i> This paper mainly summarizes the research progress of related exosome detection methods and condenses a large amount of research evidence to systematically describe the characteristics of exosomes, related mechanisms and their diagnostic and therapeutic values in gastric cancer, hoping to provide new ideas and methods for the diagnosis and treatment of gastric cancer and new opportunities for better treatment of gastric cancer patients. <i>Method</i> Through extensive reading of relevant literature, we highly summarize relevant research mechanisms and diagnostic and therapeutic values, and explore and summarize the latest hot spots. <i>Result and Conclusion</i> EXOs as an emerging research hotspot, have extensive clinical value in gastric cancer progression. Using EXOs as key targets can provide new ideas and directions for the precise diagnosis and treatment of related GI tract tumors. It is also beneficial to the early diagnosis and of gastric cancer, and provides certain research prospects for the study of related inhibitory drugs.