Mechanical Factors in the Production of Atheromatous Disease with a Critique on Antilipid Therapy

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Various mechanical factors can be implicated in the production of endothelial and arterial wall damage. These include the shear stresses of fluid dynamics, pressure stresses, and tensile and flexion stresses which can be associated with physiologic function or pathophysiologically abnormal states. These factors strongly influence the development and progression of atherosclerosis which in turn lead to additional undesired pathophysiologic events. Control of associated risk factors can lead to decreased morbidity and mortality if appropriate medical and pharmacologic therapy is undertaken.