Measurement of serum adiponectin level in hepatogen diabetes patients

Abstract

Objective To detect the serum levels adiponectin and evaluate its clinical significance in hepatic diabetes.Methods 30 hepatogenous diabetes(hepatogenous diabetes group) ,29 simple type 2 diabetes without any complications (simple type 2 diabeteswithout any complications group)and 31 normal were enrolled into this study (control group).Blood adiponectin,fasting blood glucose (FBG) ,fasting insulins (FINS) ,alanine aminotransferase (ALT) ,aspartate transferase (AST) ,total bilirubin (TBIL) and albumin (ALB),insulin sensitivity index(ISI) and insulin resistance index(HOMA-IR) were measured.The differences and the relationship of the laboratory results were compared.Results Compared with the normal group,serum adiponectin levels and ISI levels were significantly lower in other two groups (P ＜ 0.01,) while the adiponectin levels were higher in hepatogenous diabetes group than in simple type 2 diabetes group(P ＜ 0.05).The FBG and FINS and HOMA-IR levels of hepatogenous diabetes group and the FBG and HOMA-IR levels of simple type 2 diabetes group were higher significantly than that of normal group.(P ＜ 0.01),the levels of FINS of hepatogenous diabetes group were higher significantly than that of simple diabetes group (P ＜ 0.05) while the levels of FBG and ISI were lower than that of simple type 2 diabetes group(P ＜ 0.05).Adiponectin levels were negatively correlated with FBG and HOMA-IR,positively correlation with ISI and without any correlation with liver functions.Conclusion There were significant insulin resistance and abnormal metabolism of adiponectin in hepatogenous diabetes,probabily the two factors influence the occurrence and development of hepatogenous diabetes in common. Key words: Hepatic diabetes; Adiponectin; Liver function; Insulin resistance