Abstract
Background Hydrocephalus is associated with increased pulsations in the cerebral aqueduct, as demonstrated by cine MRI, as well as increased pulse pressure, as demonstrated by invasive intracranial pressure monitoring. What has yet to be elucidated is the relationship between increased pulsations and the pathophysiology of hydrocephalus. Are increased pulsations an important component of the pathophysiology, or simply an artefact of decreased intracranial compliance? We have shown that under normal circumstances, the transmission of arterial pulsations into the cranium is minimized (the so-called Windkessel effect). In this paper, we sought to demonstrate this effect directly by measuring capillary pulsations with two-photon laser scanning confocal microscopy.
Highlights
Open Access 53rd Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here.
Hydrocephalus is associated with increased pulsations in the cerebral aqueduct, as demonstrated by cine MRI, as well as increased pulse pressure, as demonstrated by invasive intracranial pressure monitoring
Are increased pulsations an important component of the pathophysiology, or an artefact of decreased intracranial compliance? We have shown that under normal circumstances, the transmission of arterial pulsations into the cranium is minimized
Summary
53rd Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here.
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