Abstract
Background In human foetal hydrocephalus and spina bifida aperta (SBA), the pathogenesis of abnormal cortical development is poorly understood. Previous reports have shown that neuroepithelial/ependymal denudation is involved in the neuropathogenesis of human foetal hydrocephalus and SBA. Interestingly, loss of the neuroepithelium/ ependyma (denudation) at the Sylvian aqueduct is preceded by defective expression of adherent and gap junction proteins. In human foetal hydrocephalus, we aimed to investigate whether abnormal cortical development is similarly associated with intercellular ependymal defects at the telencephalic (sub)ventricular zones.
Highlights
In human foetal hydrocephalus and spina bifida aperta (SBA), the pathogenesis of abnormal cortical development is poorly understood
Previous reports have shown that neuroepithelial/ependymal denudation is involved in the neuropathogenesis of human foetal hydrocephalus and SBA
Loss of the neuroepithelium/ ependyma at the Sylvian aqueduct is preceded by defective expression of adherent and gap junction proteins
Summary
Montserrat Guerra1*, Deborah Sival, Antonio Jimenez, María Dolores Dominguez Pinos, Wilfred den Dunnen, Luis Federico Bátiz, José Manuel Pérez-Figares, Esteban Rodríguez. From 54th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Vancouver, Canada. From 54th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Vancouver, Canada. 7-10 July 2010
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