Abstract
Background Over the past several years, there has been newly emerging and overlapping fields of research investigating CSF pressure and flow pulsatility (CSFp), and cerebral blood flow (CBF). It is not known whether CSFp is merely a passive epiphenomena or alternatively, plays a physiologically significant role in cerebral compliance and blood flow. Thus, the relationship between CSFp and CBF is not clearly understood. In order to study the effect of CSF pulsatility on blood flow, we have developed a novel method and device for controlling (i.e., reducing or augmenting) pulsatility.
Highlights
Over the past several years, there has been newly emerging and overlapping fields of research investigating CSF pressure and flow pulsatility (CSFp), and cerebral blood flow (CBF). It is not known whether CSFp is merely a passive epiphenomena or alternatively, plays a physiologically significant role in cerebral compliance and blood flow
In order to study the effect of CSF pulsatility on blood flow, we have developed a novel method and device for controlling pulsatility
We have developed a method of altering CSF pressure pulsatility using cardiac-gated oscillating bladder which dynamically alters CSF space volume
Summary
Over the past several years, there has been newly emerging and overlapping fields of research investigating CSF pressure and flow pulsatility (CSFp), and cerebral blood flow (CBF). It is not known whether CSFp is merely a passive epiphenomena or alternatively, plays a physiologically significant role in cerebral compliance and blood flow. The relationship between CSFp and CBF is not clearly understood. In order to study the effect of CSF pulsatility on blood flow, we have developed a novel method and device for controlling (i.e., reducing or augmenting) pulsatility
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