Abstract
Coronavirus disease 2019 (COVID-19) is a new type of respiratory infection that first emerged in December 2019 in Wuhan, Hubei, China. COVID-19 is caused by a new type of virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aims to determine the association of SNP CRP rs1800947 gene in suspected COVID-19 patients to length of stay at Al Ihsan Hospital, and Banten Hospital in June-November 2020. This study used data from 60 patients, all patients were suspect COVID-19. The subject was 29 COVID-19 people were confirmed, whereas 31 people were not. A statistics analysis due to pearson correlation and linear multi regretion. This study found a significant assosiation between the subject. The results of this study were the relationship between SNP rs1800947 and outcome, a fairly strong association level relationship was found in the SNP rs1800947 (p-value= 0.045, association= 0.537). The association between length of stay and CRP levels has a low level of association (p-value=0.015, association=0.378). The SNP genotype rs1800947 G had a longer treatment duration of 0.14778 days compared to the SNPrs1800947 C genotype. CRP levels showed that higher CRP levels increased the length of treatment compared to normal CRP levels. Where high CRP levels are at risk of 0.6330 days longer than normal CRP while very high CRP is at risk of 2.9561 days longer than Normal CRP levels. In general, the gene SNP rs1800947 and CRP levels, together affect the outcome of patients with suspected COVID-19.
Highlights
COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Where high C-reactive protein (CRP) levels are at risk of 0.6330 days longer than normal CRP while very high CRP is at risk of 2.9561 days longer than normal CRP levels (Table 4)
The association between length of stay and CRP levels has a low level of association (p-value = 0.015, association = 0.378)
Summary
COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 can cause respiratory system disorders, ranging from mild symptoms, such as flu-like symptoms, to lung infections, such as pneumonia. Some factors have been known to result in worse outcome in inflammatory diseases, including C-reactive protein (CRP). C-reactive protein (CRP) is an acute-phase protein, an early marker of inflammation or infection produced mainly in hepatocytes. CRP plays a role in inflammatory processes and the host immunological response to infection through complement pathways, apoptosis, phagocytosis, nitric oxide (NO) release, and production of cytokines.[3] CRP level has drawn interest in recent research as diagnostic tools and progression model of infections in lower respiratory tract,[4] pneumonia, and severity of COVID-19.5
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