Abstract
Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to counteract these tissue insults. Over the years, numerous studies showed the great potential of plants in promoting wound healing, by virtue of their high contents in antioxidant species. These compounds trigger a molecular cascade that collimate into the promotion of reparative processes. In this article, we report on the potential effect on wound healing of Marrubium vulgare L., a medicinal plant well known for several pharmaceutical activities. To this aim, the methanolic extract was prepared and subjected to a phytochemical investigation, quantifying the amount of marrubiin via NMR and drawing the phytochemical fingerprint via high performance liquid chromatography—ultra violet/photodiode-array detection-electrospray/mass (HPLC-UV/PAD-ESI/MS) analysis. Lastly, the antioxidant properties and wound healing potential have been evaluated.
Highlights
The plant kingdom is a precious source of healing remedies for various pathologies
Considering that phenols and related compounds may improve the proliferation of fibroblasts and the migration of cells, promoting the formation of new blood vessels and capillaries [25,32], in the present study we focus our attention on Marrubium vulgare L. leaves
According to the data reported in literature, the air-dried leaves of Marrubium vulgare L. were extracted with a solution of 80/20 methanol (MeOH)/water (v/v) [24]
Summary
The plant kingdom is a precious source of healing remedies for various pathologies. To date numerous research groups direct their efforts towards the identification of natural medicinal products and plant extracts able to prevent or treat different pathological manifestations [1]. Molecules 2017, 22, 1851 the World Health Organization (WHO), approximately 80% of people worldwide exploit traditional medicine for their health care [2]. In this context, the WHO launched the Traditional Medicine Strategy. Plant-based strategies have been widely used for wound healing and skin regeneration and, their therapeutic application dates back to the ancient times [4]. Wound is an injury that damages the dermal layer of the skin and the natural process, which leads to restore the structural and functional integrities of injured tissues, represents the wound healing [5]
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