Abstract
The present research aimed develop an innovative and efficient method for fabricating silver and palladium nanoparticles (NPs)by using exopolysaccharide (EPS) from the seaweed-associated endo-symbiotic bacteria Exiguobacterium profundum (OP919469). Through, the application is a combined precipitation approach, EPS acts as a reducing and stabilising agent for the production of NPs. The major functional groups of NPs such as C–H, N–H, C–C, and C–O stretching’s were detected. The structural morphology of NPs showed a mixture of needle, spherical, and triangle-shaped with size between 10 and 50 nm. The purity of EPS was confirmed by high-performance liquid chromatography which revealed 99.81% purity. The NPs revealed strong anti-cancer and antioxidant properties. In addition, the NPs have been shown to dose-dependent toxicity with reduced hatching, survival rate, and abnormalities in zebrafish. The biochemical assay revealed that the EPS loaded NPsdid not induce oxidative stress up to 120 hpf in contrast to hydrogen peroxide which had a significant effect (P < 0.0001) on glutathione-S-transferase, catalase (P < 0.0017), and superoxide dismutase (P < 0.0001). Overall, our finding indicates that the molecular and functional characteristics of EPS and EPS loaded NPs represent future potential applications in the drug delivery and healthcare sectors.
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