Mardin İli ve Çevresinde Serum Glukoz-6-Fosfat Dehidrogenaz Enzim Düzeyi Eksikliğinin Araştırılması

Abstract

Introduction: Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme, and the first enzyme to catalyze the pentose phosphate pathway. Our aim is to investigate the G6PD enzyme activity in Mardin province.
 Methods: Our study was divided into subgroups according to gender, age, and G6PD levels. A total of 439 individuals, 168 females and 271 males, between the ages of 2 and 80 were included in the study. G6PD enzyme activity was measured by the photometric method using the AU5800 Beckman device.
 Results: G6PD enzyme activity in the Mardin region was found to be 13.95±7.29 U/gHb. The mean G6PD enzyme activity in female patients was 14.22±6.98 U/gHb, and the mean in male patients was 13.78±7.48 U/gHb (p>0.05). When evaluated in terms of age, the G6PD enzyme activity was 14.93 (0.03-38.47) in patients aged 2-19, 13.76 (0.01-30.79) between 20-35 years old, 17.05 between 36-50 years old (0.13-27.21), 13.75 (0.05-26.99) U/gHb between 51-80 years old (p=0.301).
 Conclusion: In our study, no significant difference was found between G6PD enzyme activity in terms of age and gender. G6PD enzyme deficiency was shown as 6% relative to the reference range. A deficiency of 6.5% in male and 3.5% in female was observed. This study is valuable in that it is the first study conducted in Mardin. There is a need for larger studies to support this study locally.