Abstract
Prostatic hyperplasia, characterized by progressive hyperplasia of glandular and stromal tissues, is the most common proliferative abnormality of the prostate in aging men. A high-fat diet (HFD) usually is a major factor inducing oxidative stress, inflammation, and an abnormal state of the prostate. Mangosteen pericarp powder (MPP) has abundant xanthones which can be antioxidant, anti-inflammatory, and antiproliferative agents. Therefore, the purpose of this study was to research whether MPP supplementation can affect the progression of prostatic hyperplasia. Twenty-four male F344 rats were randomly divided into four groups, including a control group (C), prostatic hyperplasia-induced group (P), prostatic hyperplasia-induced with low-dose MPP group (PL), and induced with high-dose MPP group (PH). The P, PL, and PH groups were given weekly intraperitoneal injections of 3,2′-dimethyl-4-aminobiphenyl (DMAB) at 25 mg/kg body weight for 10 weeks, and simultaneously fed an HFD for 24 weeks. Our findings first demonstrated that MPP consumption significantly decreased the prostate weight, serum testosterone and dihydrotestosterone concentrations, protein expression of proliferating cell nuclear antigen, and malondialdehyde levels and ameliorated mitochondrial function in prostatic tissues. These results suggest that MPP supplementation could be used to attenuate the progression of prostatic hyperplasia.
Highlights
Prostatic hyperplasia, characterized by progressive hyperplasia of glandular and stromal tissues, is the most common proliferative abnormality of the prostate in aging men
After 24 weeks of experimental feeding, the food intake of prostatic hyperplasia-induced groups significantly decreased compared to the C group
We evaluated effects of Mangosteen pericarp powder (MPP) on the development of prostatic hyperplasia in F344 rats in which prostatic hyperplasia was induced by feeding an high-fat diet (HFD) and injecting DMAB
Summary
Prostatic hyperplasia, characterized by progressive hyperplasia of glandular and stromal tissues, is the most common proliferative abnormality of the prostate in aging men. Our findings first demonstrated that MPP consumption significantly decreased the prostate weight, serum testosterone and dihydrotestosterone concentrations, protein expression of proliferating cell nuclear antigen, and malondialdehyde levels and ameliorated mitochondrial function in prostatic tissues. These results suggest that MPP supplementation could be used to attenuate the progression of prostatic hyperplasia. HFD intake enhances ROS generation through elevated expressions of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits causing nuclear factor-κB (NF-κB) activation and induction of NF-κB-upregulated expressions of inflammation mediators, such as COX-2 and iNOS16 Those studies demonstrated that both oxidative stress and inflammation of the prostate can be activated by an HFD, which can transform the prostate gland into an abnormal state. Few studies of MPP treatment for prostatic hyperplasia progression have been conducted
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