MALIGNANT TRANSFORMATION OF CENTRAL OSSIFYING FIBROMA?

Abstract

Central ossifying fibroma (COF) is a benign lesion of the maxillary/mandibular bones, in which normal bone is replaced with fibrous tissue. The objective of this report is to present a case of malignant transformation of COF. A 63-year-old male presented with a known diagnosis of COF for 30 years. Initially stable, the lesion had recently begun to grow rapidly. A new histopathological diagnosis of COF was reported. Four months later, the patient returned with pain and exacerbated swelling in the angle of the mandible, visible on radiographic imaging with cortical bone expansion and a radiopaque radiating appearance. Due to oropharyngeal involvement, the patient was referred to the head and neck surgery team. The lesion was excised and diagnosed as osteosarcoma. The patient underwent further oncologic treatment and has thus far remained disease-free for two years. Central ossifying fibroma (COF) is a benign lesion of the maxillary/mandibular bones, in which normal bone is replaced with fibrous tissue. The objective of this report is to present a case of malignant transformation of COF. A 63-year-old male presented with a known diagnosis of COF for 30 years. Initially stable, the lesion had recently begun to grow rapidly. A new histopathological diagnosis of COF was reported. Four months later, the patient returned with pain and exacerbated swelling in the angle of the mandible, visible on radiographic imaging with cortical bone expansion and a radiopaque radiating appearance. Due to oropharyngeal involvement, the patient was referred to the head and neck surgery team. The lesion was excised and diagnosed as osteosarcoma. The patient underwent further oncologic treatment and has thus far remained disease-free for two years.