Male sex, discoid lupus erythematosus, and lower limb involvement are associated with systemic lupus in lupus panniculitis patients: A multicenter case series of 74 patients

Abstract

To the Editor: Lupus erythematosus panniculitis (LEP) occurs in 1% to 3% of patients with cutaneous lupus erythematosus 1 Requena L. Sánchez Yus E. Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol. 2001; 45 (quiz 362-364): 325-361 Abstract Full Text Full Text PDF PubMed Scopus (390) Google Scholar ,2 Sánchez N.P. Peters M.S. Winkelmann R.K. The histopathology of lupus erythematosus panniculitis. J Am Acad Dermatol. 1981; 5: 673-680 Abstract Full Text PDF PubMed Scopus (119) Google Scholar and is characterized by recurrent nodules or plaques that can evolve to lipoatrophy 1 Requena L. Sánchez Yus E. Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol. 2001; 45 (quiz 362-364): 325-361 Abstract Full Text Full Text PDF PubMed Scopus (390) Google Scholar ,3 Rangel L.K. Villa-Ruiz C. Lo K. et al. Clinical characteristics of lupus erythematosus panniculitis/profundus: a retrospective review of 61 patients. JAMA Dermatol. 2020; 156: 1264-1266 Crossref PubMed Scopus (3) Google Scholar and impair quality of life. 4 Ogunsanya M.E. Cho S.K. Hudson A. Chong B.F. Validation and reliability of a disease-specific quality-of-life measure in patients with cutaneous lupus erythematosus. Br J Dermatol. 2019; 180: 1430-1437 Crossref PubMed Scopus (10) Google Scholar In a recent study of 61 patients with LEP, the proportion of systemic lupus erythematosus (SLE) was 21%. 3 Rangel L.K. Villa-Ruiz C. Lo K. et al. Clinical characteristics of lupus erythematosus panniculitis/profundus: a retrospective review of 61 patients. JAMA Dermatol. 2020; 156: 1264-1266 Crossref PubMed Scopus (3) Google Scholar Little is known about the differences between LEP with or without SLE 5 Petri M. Orbai A.M. Alarcón G.S. et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012; 64: 2677-2686 Crossref PubMed Scopus (1) Google Scholar and baseline features associated with the occurrence of sequelae.