Abstract
BackgroundPort-Wine Birthmarks (PWB) are congenital capillary malformations requiring multiple treatments. Optical coherence tomography (OCT), a non-invasive imaging technique, characterizes vessels in cutaneous vascular lesions including PWBs. ObjectiveTo assess variability in blood vessel characteristics within and between individual PWBs. MethodsOCT was used to measure blood vessel density (%) and modal vessel diameter (micrometres) at increments of 0.05 mm from skin surface to a depth of 0.50 mm at several adjacent spots of single PWBs in this cross-sectional study. Average ratios of vessel density and diameter in affected to control skin were obtained for each PWB by averaging data for all spots within a lesion. Statistical analysis was performed with linear mixed effects model using SPSS (IBM, Corp.). ResultsThere was great variability in vessel density and diameter within and between PWBs. Depths where average ratios of vessel density were consistently greater in affected to control skin were shallow, between 0.15 - 0.2 mm deep from the skin surface. LimitationsSmall sample size and device inability to measure diameters smaller than 20 micrometres. ConclusionThere is variability in vessel density and diameter within and between PWBs. Individualized treatment planning guided by OCT mapping should be studied further.
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