Magnetically driven microrobotic system for cancer cell manipulation.

Abstract

Lab-on-a-chip applications, such as single cell manipulation and targeted delivery of chemicals, could greatly benefit from mobile untethered microdevices able to move in fluidic environments by using magnetic fields. In this paper a magnetically driven microrobotic system enabling the controlled locomotion of objects placed at the air/liquid interface is proposed and exploited for cell manipulation. In particular authors report the design, fabrication and testing of a polymeric thin film-based magnetic microrobot (called "FilmBot") used as a support for navigating cancer cells. By finely controlling magnetic film locomotion, it is possible to navigate the cells by exploiting their adhesion to the film without affecting their integrity. Preliminary in vitro tests demonstrated that the magnetic thin film is able to act as substrate for T24 bladder cancer cells without affecting their viability and that film locomotion can be magnetically controlled (with a magnetic field and a gradient of 6 mT and 0.6 T/m, respectively) along specific directions, with a mean speed of about 3 mm/s.