Abstract
A unique noncontact single cell manipulation technique based on the actuation of magnetic nanorods (MNRs) or clusters (MCs) by nonuniform alternating magnetic fields (nuAMFs) is demonstrated. Compared to the actuation of MNRs/MCs by conventional magnetophoresis, the motion of MNRs/MCs actuated by nuAMFs can be tuned by additional parameters including the shape of MNRs/MCs and the frequency of the applied magnetic fields. The manipulation of a single cell by an actuated MNR/MC are divided into five stages, i.e., approaching, pushing, carrying, dragging, and releasing. The interactions between the MNR/MC and the cell in these stages are investigated in detail both experimentally and numerically. Other applications of cell manipulation, such as concentrating cells at target locations and accumulating MNRs/MCs onto a single cell, are also demonstrated. The single cell manipulation system is simple, low-cost, and low-power consumption, and helps advance the state-of-the-art of single-particle manipulation.
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