Abstract
A hybrid magnetic material γFe2O3@Sh@cu2O was easily prepared from Shilajit (Sh) decorated Fe3O4 and copper acetate. The prepared magnetic hybrid material was fully characterized using different analysis, including Fourier transform infrared (FT-IR), X-ray diffraction (XRD), inductively coupled plasma (ICP), scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM) thermal gravimetric analysis (TGA) and Brunauer–Emmett–Teller (BET). All these analysis revealed that during coating of Fe3O4@Sh using copper salt (II), synchronized redox sorption of CuII to CuI occurs at the same time as the oxidation of Fe3O4 to γFe2O3. This magnetic catalyst exhibited excellent catalytic activity for regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles via one pot three-component click reaction of sodium azide, terminal alkynes and benzyl halides in the absence of any reducing agent. High yields, short reaction time, high turnover number and frequency (TON = 3.5 * 105 and TOF = 1.0 * 106 h−1 respectively), easy separation, and efficient recycling of the catalyst are the strengths of the present method.
Highlights
Presented by Sharpless [1] in 2001, the “click chemistry” consists of clipping two molecules to one another, as one closes a snap
The final product of this three-component reaction here is 1,4-diaryl-1,2,3-triazole. These results have successfully demonstrated that this catalyst can be used for the synthesis of the click synthesis of 1,4-disubstiuted-1,2,3-triazoles
In summary, a recyclable hybrid magnetic mesoporous material γFe2O3@Sh@Cu2O was developed by click reaction between Sh decorated F e3O4 and copper acetate
Summary
Presented by Sharpless [1] in 2001, the “click chemistry” consists of clipping two molecules to one another, as one closes a snap. Not all molecules can be clipped to any other. While click chemistry has everything to seduce the world of life, it has a weak point: its kinetics is extremely low, the frequent use of a According to the literature, several sources make it possible to obtain C uI ions in the reaction mixture. In situ reduction of copper(II) salts in the form of copper sulphate pentahydrate (CuSO4·5H2O) or copper acetate (Cu(OAc)2), is the most commonly encountered method. It requires the introduction of an excess reducing agent, usually sodium ascorbate. The reaction is done by adding a large excess of copper to the azide/alkyne mixture.
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