Synthesis of magnetically separable catalyst Cu-ACP-Am-Fe3O4@SiO2 for Huisgen 1,3-dipolar cycloaddition

Abstract

The present manuscript elicits the use of novel magnetically separable silica coated copper (Cu-ACP-Am-Fe3O4@SiO2) as a heterogeneous nanocatalyst for the Huisgen 1,3-dipolar cycloaddition reaction of alkyl or aryl halide, sodium azide and terminal alkyne, which provide a series of 1,4-disubstituted-1,2,3-triazoles. The catalyst was characterized by various physicochemical techniques such as Powder X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-Ray Spectroscopy(EDS), Thermogravimetric analysis (TGA-DSC), X-ray Photoelectron spectroscopy (XPS) and Vibrational sampling magnetometer (VSM). The acquisition of this nanocatalyst is also exemplified by employing reusability test and recycling of synthesized catalyst was achieved multiple times just by sequestering with an external magnet. It is noteworthy that the key-features like mild reaction conditions, simple work-up, High turnover number (TON), high turnover frequency (TOF), no use of hazardous organic solvents, easy recovery and reusability of the catalyst makes the present protocol more fascinating from an environmental and economic point of view.