Abstract
Objective: To investigate the effect of magnesium sulfate combined with nifedipine in the treatment of pregnancy-induced hypertension syndrome (PIHS).
 Methods: Total 118 pregnant women with PIHS who were admitted to our hospital from April 2017 to June 2018 were randomly divided into control group (59 cases) and observation group (59 cases). The observation group was treated by magnesium sulfate in combination with nifedipine, while the control group was treated by magnesium sulfate. The therapeutic effect, serum leukaemia inhibitory factor (LIF), Apelin level, blood pressure, blood viscosity, urinary protein, S/D and Umbilical Artery Resistance Index (UARI) were compared between the two groups.
 Results: The effective rate of the observation group was 94.9%, higher than 83.1% of the control group, and the difference was statistically significant (P<0.05). The decrease level of systolic and diastolic blood pressure in the observation group was better than that in the control group, and the difference was statistically significant (P<0.05). The decrease of blood viscosity, urinary protein, S/D and UARI in the observation group was greater than that in the control group, and the difference was statistically significant (P<0.05). The improvement of serum LIF and Apelin levels in the observation group was better than that in the control group (P<0.05), and the difference was statistically significant (P<0.05).
 Conclusion: Magnesium sulfate combined with nifedipine in the treatment of PIHS has a significant effect, which can effectively control edema, blood pressure, proteinuria and protect kidney. It is worth clinical promotion.
 doi: https://doi.org/10.12669/pjms.36.1.706How to cite this:Xiang C, Zhou X, Zheng X. Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension. Pak J Med Sci. 2020;36(1):---------. doi: https://doi.org/10.12669/pjms.36.1.706
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Highlights
Pregnancy-induced hypertension syndrome (PIHS) mainly occurs after 20 weeks of pregnancy and in the early stage of puerperium
The overall effective rate of the observation group was 94.9%, which was significantly higher than 83.1% in the control group; the difference was statistically significant (P
The results of this study showed that the the decrease amplitudes of SBP and DBP of the observation group were more obvious than those of the control group, indicating that nifedipine combined with magnesium sulfate had significant effect in the treatment of PIHS and could effectively control blood pressure
Summary
Pregnancy-induced hypertension syndrome (PIHS) mainly occurs after 20 weeks of pregnancy and in the early stage of puerperium. Causes of PIHS include placental ischemia, immunity decline and heredity of pregnant women.[1,2,3] Its main clinical symptoms manifest as hypertension, edema, proteinuria, and even convulsions, coma, cerebrovascular accidents, placental abruption, fetal distress, intrauterine death and heart and kidney failure.[4,5] The morbidity of PIHS is 9.4%6 in China and 1%~12% abroad.[7] It can seriously affect the health of mothers and infants. It is the main cause of morbidity and death of mothers and perinatals
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