Abstract
Magnesium Serum Concentrations in Patients with Dementia Vs. Controls; A Systematic Review and Meta-Analysis
Highlights
The role of magnesium in the pathogenesis of dementia and other degenerative disorders has focused increased attention in recent years [1,2]
Our objective was to conduct a systematic review and meta-analysis in order to verify whether dementia and Alzheimer disease are associated with lower serum magnesium concentrations
We reviewed the papers for demographics and details on diagnosis and measured magnesium levels
Summary
The role of magnesium in the pathogenesis of dementia and other degenerative disorders has focused increased attention in recent years [1,2]. There is evidence that glutamate release and intake are chronically disturbed in Alzheimer’s disease, and glutamate levels are possibly increased in the synaptic cleft, with resultant calcium influx to postsynaptic neurons and activation of the calcium - related enzyme system. This leads to production of free radicals, protein destruction, lipid peroxidation, and neuron death with DNA destruction [4]. Other research found that both low and high serum magnesium levels were associated with an increased risk of Alzheimer’s disease and mixed dementia. Our objective was to investigate the possible association between dementia and hypomagnesaemia
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