Abstract
Amantadine for the Treatment of Parkinson’s Disease and its Associated Dyskinesias
Highlights
In 1968, a 58-year-old patient with moderately severe Parkinson’s Disease (PD) reported that, while taking amantadine to prevent symptoms of the flu, a remarkable remission of cogwheel rigidity and tremor was found to occur
The analysis showed a significant reduction in Standard Mean Difference (SMD) for Unified Parkinson’s Disease Rating Scale (UPDRS) IV (SMD -1.45; 95% CI: -2.28 to -0.63) and UPDRS III (SMD -0.41; 95% CI: -0.69 to -0.12) after treatment with amantadine
In the most recent Movement Disease Society (MDS)-commissioned evidence-based medicine review of treatments for the motor symptoms of PD covering the results of trials up to December 31, 2016, new conclusions for the treatment of dyskinesias were reported in which 3 new high-quality studies using amantadine were identified [12, 27,28,29]
Summary
In 1968, a 58-year-old patient with moderately severe PD reported that, while taking amantadine to prevent symptoms of the flu, a remarkable remission of cogwheel rigidity and tremor was found to occur. Electronic searches of The Cochrane Controlled Trials Register issue 3 (2001), Medline (1966-2001), Embase (1974-2001), Clinicaltrials.gov (2001) and other databases as well as manual searches of reference lists from selected studies/reviews were examined in order to select RCTs comparing amantadine with placebo for the treatment of dyskinesias in patients with a clinical diagnosis of idiopathic PD.
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