Machine-learning-based computed tomography radiomic analysis for histologic subtype classification of thymic epithelial tumours

Abstract

PurposeTo evaluate the performance of machine-learning-based computed tomography (CT) radiomic analysis to differentiate high-risk thymic epithelial tumours (TETs) from low-risk TETs according to the WHO classification. MethodThis retrospective study included 155 patients with a histologic diagnosis of high-risk TET (n = 72) and low-risk TET (n = 83) who underwent unenhanced CT (UECT) and contrast-enhanced CT (CECT). The radiomic features were extracted from the UECT and CECT of each patient at the largest cross-section of the lesion. The classification performance was evaluated with a nested leave-one-out cross-validation approach combining the least absolute shrinkage and selection operator feature selection and four classifiers: generalised linear model (GLM), k-nearest neighbor (KNN), support vector machine (SVM) and random forest (RF). The receiver-operating characteristic curve (ROC) and the area under the curve (AUC) were used to evaluate the performance of the classifiers. ResultsThe combination of UECT and CECT radiomic features demonstrated the best performance to differentiate high-risk TETs from low-risk TETs for all four classifiers. Among these classifiers, the RF had the highest AUC of 0.87, followed by GLM (AUC = 0.86), KNN (AUC = 0.86) and SVM (AUC = 0.84). ConclusionsMachine learning-based CT radiomic analysis allows for the differentiation of high-risk TETs and low-risk TETs with excellent performance, representing a promising tool to assist clinical decision making in patients with TETs.