Abstract

Lymphocyte Subset (CD3, CD4 and CD8 Cells) and their Ratios in HIV patients on Highly Active Antiretroviral Therapy (HAART) and HAART Naïve Patients

Highlights

  • Lymphocytes form part of the blood cells involve in the fight against infection in the immune system

  • This study sought to determine the lymphocyte differentials in seropositive HIV patients on Highly Active Antiretroviral Therapy (HAART) and HAART naïve

  • The pathogenic effect of HIV virus resulted in significantly low mean levels of CD4, CD8, CD4/CD3 and CD4/CD8 ratio among on HAART and HAART naïve patients compared to control group

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Summary

Introduction

Lymphocytes form part of the blood cells involve in the fight against infection in the immune system. They function in the adaptive immunity where the B-lymphocyte functions under the humoral immunity and the T-lymphocyte functions under the cell-mediated immunity which is involve in the defence against intracellular microbes The latter is further classified as CD4+ and CD8+ with the CD standing for Cluster of Differentiation. Lymphocytes form part of blood cells involve in the fight against infection in the immune system. These cells are mostly implicated in the pathogenesis of HIV/AIDS. Objective: This study sought to determine the lymphocyte differentials in seropositive HIV patients on HAART and HAART naïve. Conclusion: The pathogenic effect of HIV virus resulted in significantly low mean levels of CD4, CD8, CD4/CD3 and CD4/CD8 ratio among on HAART and HAART naïve patients compared to control group

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