Abstract
Effect of Plant Extracts on Innate Immunity of Skin Cells: Investigations on Human Keratinocyte Cell Lines
Highlights
The skin is a natural barrier between the body and the environment and is colonized by a large number of microorganisms
After 60 minutes of treatment with R. frangula hot water extracts, a significant increase of reactive oxygen species (ROS) production is observed for the following concentrations 0.5 mg.mL-1, 1 mg.mL-1, 2 mg.mL-1, 3 mg.mL-1 et 4 mg.mL-1 compared with HaCaT cells treated with PBS (Phosphate Buffer saline) buffer only
After 60 minutes of treatment with C. myrrha hot water extracts, a significant increase of ROS production is observed for the concentrations 0.5 mg.mL-1, 1 mg.mL-1, 2 mg.mL-1, 3 mg.mL-1 et 4 mg.mL-1 compared to HaCaT cells treated with PBS
Summary
The skin is a natural barrier between the body and the environment and is colonized by a large number of microorganisms. Environmental aggressions such as UV exposure, tobacco and pathogenic micro-organisms are known to have deleterious effects on skin ultrastructure resulting in a loss of its protective function. Chronic or excessive environmental stresses lead to persistent inflamatory disease considered as a major source of skin cancers and premature ageing [4]. As a result of these various aggressions, the skin is constantly exposed to reactive oxygen species (ROS) production causing the so-called oxidative stress. Received: April 23, 2020 Accepted: June 29, 2020 Published: July 27, 2020
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