Abstract
Distant metastases generally indicate disseminated disease and the standard treatment for these patients is palliative chemotherapy. Retrospective series showed that selected patients with metastatic lung cancer and a solitary extrathoracic disease could be effectively treated with curative intention by resection of both primary tumor and the single site of metastatic disease. According to current data, adrenalectomy might be considered as an alternative option for patients with isolated adrenal metastases. Significant morbidity and mortality may be happened by these procedures, and a cautious analysis of pros and cons should be discussed with the patient. We present a review of the literature and updated recommendations focusing lung cancer with solitary adrenal metastasis.
Highlights
Isolated adrenal metastasis are reported in 1,6 -3,5% of patients with primary non-small cell lung cancer (NSCLC), presenting with resectable tumors, and it increases up to 40% as the disease progresses[1,2].The setting of distant metastasis generally indicates disseminated disease and the standard treatment for these patients is palliative chemotherapy
We present a review of the literature and updated recommendations focusing lung cancer with solitary adrenal metastasis
The results of adrenal metastasectomy should be analyzed from the point of view according to the critical factors that can affect survival
Summary
Isolated adrenal metastasis are reported in 1,6 -3,5% of patients with primary non-small cell lung cancer (NSCLC), presenting with resectable tumors, and it increases up to 40% as the disease progresses[1,2]. The setting of distant metastasis generally indicates disseminated disease and the standard treatment for these patients is palliative chemotherapy. Retrospective series suggest that some stage IV non-small-cell-lung cancer (NSCLC) patients with a solitary synchronous/metachronous extrathoracic metastatic disease (“micrometastatic disease”) might be cured by resection of both primary tumor and isolated metastases[2,3]. Since 1982, when Twomey et al[4] reported on prolonged survival after adrenalectomy, introducing the concept of curative management of patients with lung cancer and isolated adrenal metastases, many reports have addressed this topic and confirmed the feasibility of such approach
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
