Metastasectomy of Solitary Adrenal Metastasis From Small Cell Lung Cancer.

Dat Cao Pham,Jason Hew,Bradford S Hoppe,Ziad Awad,Ke Ning

doi:10.1177/2324709617740909

Abstract

Most extensive-stage small cell lung cancers have disseminated disease at diagnosis, and solitary adrenal metastasis from small cell lung cancer is rare. We report the case of a 51-year-old man with extensive-stage small cell lung cancer with solitary right adrenal metastasis (T2N0M1), who was cured with resection of primary tumor, chemotherapy (cisplatin, etoposide), adrenalectomy, consolidative thoracic radiotherapy, and prophylactic cranial irradiation. He remained cancer free, 7.5 years since diagnosis. For small cell lung cancer with solitary adrenal gland metastasis, metastasectomy combined with chemotherapy and radiotherapy can be curative and enable long-term survival. This treatment approach should be further studied, and similar cases should be reported.

Highlights

Small cell lung cancer accounts for about 15% of all lung cancers
We report the case of a man with extensive-stage small cell lung cancer with solitary metastasis to the right adrenal gland, who was cured with resection of primary tumor, chemotherapy, adrenalectomy, and consolidative thoracic radiotherapy
PantPurohit et al reported of a patient with limited-stage small cell lung cancer, who developed a solitary metastasis to the adrenal gland 5 years after diagnosis and was successfully treated with left adrenalectomy with a disease-free survival of more than 66 months since adrenalectomy.[2]

Summary

Introduction

Small cell lung cancer accounts for about 15% of all lung cancers. it is sensitive to chemotherapy and radiotherapy, it carries a poorer prognosis compared with non– small cell lung cancer due to its aggressive clinical course, early hematogenous metastasis, rapid doubling time, and high growth fraction. Keywords small cell lung cancer, solitary adrenal gland metastasis, adrenalectomy, metastasectomy, treatment In extensive-stage small cell lung cancer, solitary metastasis to the adrenal gland is rare and the role of adrenalectomy has not been studied.

Results

Conclusion