Abstract
Traditionally used medicinal plants have been a source of relief in the control of different types of diseases throughout the globe. Economically backward people, who resides in remote areas of developing countries, rely heavily on indigenous way of get rid of parasitic infections using folk medicine. <i>Alpinia nigra</i> is one such medicinal plant, widely used in different parts of North-East India to cure intestinal helminth infection. Essential oils of different species of Alpinia contain flavonoids, terpenoids and kavalactones which have been in used to cure inflammation, hypertension, bacterial and helminth infection. In this review, the crude alcoholic extract of <i>A. nigra</i> that causes destruction and degeneration of surface architecture of tegument, inhibit energy metabolism related enzymes and also enzyme responsible for neuromuscular co-ordination are discussed.
Highlights
Indigenous system of herbal therapy is becoming an increasingly attractive approach to control parasitic infection, in developing countries
Mortality and Motility Study Studies on mortality and motility conducted on intestinal giant fluke, Fasciolopsis buski to see the anthelmintic efficacy of A. nigra crude-extract and reference drug, praziquantel (PZQ) revealed that on exposure to different concentrations of plant extract as well as PZQ, the parasites became immobile, followed by flaccid paralysis and death
Of the two glycolytic enzymes studied, higher staining intensity has been observed for malate dehydrogenase (MDH) compared to lactate dehydrogenase (LDH) in control parasites which indicate the presence of higher activities of MDH enzyme in F. buski (Fig. 6a & 7a)
Summary
Indigenous system of herbal therapy is becoming an increasingly attractive approach to control parasitic infection, in developing countries. Helminth and helminthic infections (helminthiasis) remain to be one of the major health problems affecting billions of people all over the world[1,2]. They are the most common infectious agents of human beings that contribute in the wide spread occurrence of undernourishment, anaemia, eosinophilia and pneumonia[3]. Anthelmintic Medicinal Plant of North-East India various helminthic infections[26,27,28,29,30] Several such studies based on traditional medicinal knowledge were done in Indian sub-continent to test the putative anthelminthic activity of different plants. The pollen of A. nigra is monad, inaperture spheroidal, small size, isopolar, radial symmetry and sculpturing is echinate[36]
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