Abstract
Current therapies for neurodegenerative diseases offer only limited benefits to their clinical symptoms and do not prevent the degeneration of neuronal cells. Neurological diseases affect millions of people around the world, and the economic impact of treatment is high, given that health care resources are scarce. Thus, many therapeutic strategies to delay or prevent neurodegeneration have been the subject of research for treatment. One strategy for this is the use of herbal and essential oils of different species of medicinal plants because they have several bioactive compounds and phytochemicals with neuroprotective capacity. In addition, they respond positively to neurological disorders, such as dementia, oxidative stress, anxiety, cerebral ischemia, and oxidative toxicity, suggesting their use as complementary treatment agents in the treatment of neurological disorders.
Highlights
A number of complementary treatment are currently being investigated to provide neuroprotection or to treat neurodegenerative diseases
Piper methysticum is popularly known as Kava or Kava-kava, a perennial shrub belonging to the Pacific Ocean pepper family (Piperaceae) with historical and cultural significance is described in the literature as a compound that has neuroprotective action and anxiolytic effects and is used in sedatives, and analgesics, being anti-inflammatory, anticonvulsant and anti-ischemic
The results demonstrated that MPP-induced apoptosis of PC12 cells was significantly prevented by guanosine pretreatment for 3 h
Summary
A number of complementary treatment are currently being investigated to provide neuroprotection or to treat neurodegenerative diseases. Recent advances in understanding the pathophysiological mechanisms of neurological disorders have led to new strategies in drug development. Scientific research has explored which stimuli and substances can contribute to neural cell plasticity, resulting in improved quality of life for people with depression, Alzheimer’s Disease (AD), Parkinson’s Disease (PD), among other nervous system-related disorders [6]. A complementary treatment proposed is the use of herbal medicines, which have scientific relevance in the treatment of neurological diseases because they contain multiple compounds and phytochemicals that can have neuroprotective effect, with a consequent beneficial action for health in different neuropsychiatric and neurodegenerative disorders [8]
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