Abstract
We have demonstrated previously by cDNA vinalysis that VIP is derived together with PHI-like peptide (PHM) from a common precursor (preproVIP) in a humain neuroblastoma cell line called NB-OK-1. The humain neuroblastosma cell line produces and releases the large variants (8K and 18K dalton) of VIP-like immunoreactivity (IR-VIP) in response to dibutyryl cAMP stimulation. The purpose of the present study is to purify the 8Kd vind 18Kd forms of VIP-relaited peptides from the human neuroblastoma culture media and to characterize their structure. IR-VIP in the culture media was fractionated with 40% to 60% of saturated ammonium sulfate (SAS)
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