Abstract
The study is concerned with the pharmacological and clinical evaluation of cephacetrile as given by the results obtained in 23 patients with lower respiratory infections. The criteria employed comprised not only pharmacokinetic parameters such as serum and urine concentrations and the serum half-life, but also bacteriological and clinical data obtained in the course of careful examinations carried out before, during, and after treatment. The studies conducted for this purpose included various laboratory tests, as well as differential blood counts, tests of respiratory function, sputum investigations, and tests of hepatic and renal function. In the patients under review, most of whom were old (average age 62 years) and in moderate or poor condition, treatment with cephacetrile (1 g twice daily i. m.) enabled a complete clinical success to be achieved in 69 % of cases, a partial success being obtained in a further 13 %. The bacteriological and laboratory findings (e.g. improvement in the sputum characteristics) correlated well with the clinical response. Cephacetrile was well tolerated; in particular, it appeared to have no nephrotoxic properties.
Published Version
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