Low power, low noise, compact amperometric circuit for three-terminal glucose biosensor

Abstract

A low power, low noise, and compact amperometric circuit architecture, which can be used with three-terminal electrochemical glucose sensor is presented. The architecture, developed from the threshold voltage referenced current source configuration, provides the reference voltage required for electrochemical reaction and converts the reaction current into corresponding voltage. The feasibility of this architecture is demonstrated by the fabrication of the circuit in 0.35 µm CMOS technology. Measurements are performed with the electrical model of three-terminal electrochemical sensor and with the three-terminal glucose biosensor as well. Circuit occupies 125 µm × 340 µm and consumes 199 µW of power and generates 312 µV rms noise. The proposed architecture is suitable for portable electrochemical sensing devices especially for glucose sensing.