Abstract
The binding characteristics of radiolabelled β-nerve growth factor ([ 125I]NGF) have been determined on membrane preparations of basal forebrain from Alzheimer's disease (AD) brain and age-matched normal brains. [ 125I]NGF binds in a specific fashion indicative of a single receptor and is not displaced with μM concentrations of cytochrome c, insulin or epidermal growth factor (EGF). The mean dissociation constant ( K d) and the mean capacity ( B max) of the NGF receptor were not significantly different between the 5 AD and 5 normal basal forebrain samples examined. Choline acetyltransferase (ChAT) activity was significantly reduced ( P ⩽ 0.001) in AD cerebral cortical samples compared with normal tissue.
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