Abstract
We investigated the relationship between serotonergic and dopaminergic specific binding transporter ratios (SBRs) over 4years in Parkinson's disease (PD) patients. We assessed serotonergic innervation's potential compensatory role for dopaminergic denervation, association with PD symptoms, and involvement in the development of levodopa-induced dyskinesia (LID). SBRs of the midbrain and striatum were evaluated from [I-123] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane SPECT images at baseline and after 4years. Correlations between SBRs and PD symptoms were analyzed, alongside interval changes. Study included 177 PD patients (110 males, 67 females; mean age 61.0±9.0years). Significant worsening was observed in Hoehn and Yahr staging and Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II and III scores over 4years (p<0.05, p<0.001, and p<0.001, respectively). SBRs of the caudate, putamen, and midbrain declined significantly (p<0.001). Midbrain and striatal SBRs correlated significantly at both baseline and 4-year follow-up (p<0.0001). Striatal SBRs correlated significantly with MDS-UPDRS II and III scores at both time points, while midbrain SBRs correlated with changes in MDS-UPDRS III scores over the 4years (p<0.01). Putamen and midbrain SBRs at 4years were significantly lower in patients who developed LID compared to those who did not (p<0.05). The study demonstrates correlations between midbrain and putamen SBRs and MDS-UPDRS scores over 4years in PD patients. Midbrain serotonin dysfunction may contribute to the development of LID.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call