Abstract
Long noncoding RNAs have recently been proven to regulate tumorgenesis in many cancers. However, their biological functions in glioblastoma remain largely unknown. Here we found an uncharacteristic lncRNA lncHERG that is highly expressed in human glioblastoma (GBM). We found that lncHERG knockdown inhibited cell proliferation, migration and invasion in glioblastoma in vitro and in vivo. Moreover, the higher expression of lncHERG in patients with glioblastoma indicated lower survival rate and poorer prognosis. Mechanistically, we found that lncHERG can serve as a sponge for miR-940 which is a tumor suppressor in cervical cancer and whose function has not been defined in glioblastoma. We showed that miR-940 was down-regulated in glioblastoma tissues compared to peritumor tissues. LncHERG knockdown impaired cell proliferation, migration and invasion while inhibition of miR-940 in the meantime reversed this trend. In conclusion, our study highlights the essential role of lncHERG in glioblastoma by acting as a competing endogenous RNA of miR-940, which may serve as a new prognostic biomarker in glioblastoma.
Highlights
Glioblastoma (GBM), the most common and aggressive brain tumor around the world, leads to a large amount of deaths each year [1, 2]
Our study highlights the essential role of lncHERG in glioblastoma by acting as a competing endogenous RNA of miR-940, which may serve as a new prognostic biomarker in glioblastoma
We showed that lncHERG depletion impaired proliferation, migration and invasion of glioblastoma in vitro and in vivo
Summary
Glioblastoma (GBM), the most common and aggressive brain tumor around the world, leads to a large amount of deaths each year [1, 2]. Radiotherapy and chemotherapy were the main methods for treatment of GBM patients [3,4,5,6]. The 5-year overall survival rate of patients with GBM is less than 3% [7, 8]. Due to the infiltrative growth of glioblastoma, the rate of tumor recurrence is very high [5]. There is no effective method for fully treatment of glioblastoma so far. In order to develop new and effective therapeutic management of GBM, it is an urgent and necessary to define the molecular mechanism that regulates the genesis of glioblastoma
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
