Abstract
Enhanced detection of multiple targets such as self-assembled monolayer (SAM) formation,DNA hybridization, and ethanol ambient changes was explored using localized surfaceplasmon resonance (LSPR) excited by metallic surface nanogratings. The sensitivityenhancement depends on the target as well as the nanostructure with a maximum at 242%over a conventional structure when detecting an 11-mercaptoundecanoic acid SAM with anLSPR structure of 200 nm period. The measured enhancement shows smallertarget-dependent variance when detecting various layered biointeractions, whilestructure-dependent variance was much larger. The result suggests the feasibility of theefficient detection of multiple biointeractions at enhanced sensitivity and extends theapplicability of a nanostructured LSPR biosensor for diverse biomolecular events.
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